Colloquium - Ken Dill (Stony Brook University) How Cellular Decisions are Encoded in its Proteome's Physical Chemistry

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Ken Dill (Stony Brook University) 3/27/18 colloquium speake
March 27, 2018
3:30PM - 4:30PM
Location
1080 Physics Research Building - Smith Seminar Room - reception at 3:30pm in the Atrium

Date Range
Add to Calendar 2018-03-27 15:30:00 2018-03-27 16:30:00 Colloquium - Ken Dill (Stony Brook University) How Cellular Decisions are Encoded in its Proteome's Physical Chemistry

Some cell behaviors can be explained by the physics of the cell proteome, the full complement of the cell's proteins.  For example, we believe that heating kills cells by denaturing their proteins.  Salt slows cell growth by overcrowding the proteins.  Oxidative damage in aged cells may involve electrostatic unfolding.  We explore these properties using physical chemical models.  We also explore proteostasis, the machinery that keeps the cell's proteins folded and disaggregated, particularly under stress.  We find many ways in which evolution has encoded `cleverness' into proteostasis decision-making.

1080 Physics Research Building - Smith Seminar Room - reception at 3:30pm in the Atrium Department of Physics physics@osu.edu America/New_York public
Description

Some cell behaviors can be explained by the physics of the cell proteome, the full complement of the cell's proteins.  For example, we believe that heating kills cells by denaturing their proteins.  Salt slows cell growth by overcrowding the proteins.  Oxidative damage in aged cells may involve electrostatic unfolding.  We explore these properties using physical chemical models.  We also explore proteostasis, the machinery that keeps the cell's proteins folded and disaggregated, particularly under stress.  We find many ways in which evolution has encoded `cleverness' into proteostasis decision-making.