Clustered regularly interspaced short palindromic repeats (CRISPR) enable editing of the genetic materials in living cells. By changing the genetic information at specifically targeted regions in the genome, scientist now use CRISPR to make precise genetic alterations, study their functions and correct disease associated genetic mutations. In this talk, I will introduce CRISPR-based technologies and their major application areas. I will then present the results of our studies on CRISPR-based genome-scale knockout screening, locus specific epigenetic editing and chromatin imaging approaches.
1080 Physics Research Building - Smith Seminar Room - reception at 3:45pm in the Atrium Department of Physics physics@osu.edu America/New_York publicClustered regularly interspaced short palindromic repeats (CRISPR) enable editing of the genetic materials in living cells. By changing the genetic information at specifically targeted regions in the genome, scientist now use CRISPR to make precise genetic alterations, study their functions and correct disease associated genetic mutations. In this talk, I will introduce CRISPR-based technologies and their major application areas. I will then present the results of our studies on CRISPR-based genome-scale knockout screening, locus specific epigenetic editing and chromatin imaging approaches.
