Kinesin-14s are microtubule-based motor proteins that play important roles in cell division. They were originally thought to be minus-end-directed nonprocessive motors that exhibit directional preference toward the microtubule minus ends in multi-motor ensembles but are unable to generate processive (continuous) motility on single microtubules as individual motors. During the past 5 years, we and others have discovered several “unconventional” kinesin-14 motors that all contain the ability to generate processive motility as individual motors on single microtubules. In this talk, I will present a series of unexpected yet exciting findings from my lab that have markedly expanded current view of the design and operation principles of kinesin-14 motors.
You are here
BioPhysics seminars - Weihong Qiu (Oregon State University) Kinesin-14s: Moving Into a New Paradigm
Monday, August 27, 2018 - 10:30am to 11:30am
1080 Physics Research Building - Smith Seminar Room