Ohio State nav bar

BioPhysics Seminar - Greg Bowman (Johns Hopkins University) Recognition of the Nucleosome by a Chromatin Remodeler

Greg Bowman - Johns Hopkins University - 12/7/17 BioPhysics Seminar speaker
December 7, 2017
11:00AM - 12:00PM
1080 Physics Research Building - Smith Seminar Room

Date Range
Add to Calendar 2017-12-07 11:00:00 2017-12-07 12:00:00 BioPhysics Seminar - Greg Bowman (Johns Hopkins University) Recognition of the Nucleosome by a Chromatin Remodeler Chromatin remodelers are multidomain machines that reposition nucleosomes along genomic DNA using a helicase-like ATPase motor. Yet how the remodeler ATPase is regulated to achieve particular remodeling outcomes has been unclear. I will discuss our recent biochemical work describing the domain architecture for the Chd1 remodeler on the nucleosome. In contrast with what has been described for other remodelers, this domain organization suggests an inhibitory mechanism for sensing DNA flanking the nucleosome. I will present a model for how domain-domain communication allows Chd1 to slide nucleosomes away from bound transcription factors and generate evenly spaced nucleosome arrays. 1080 Physics Research Building - Smith Seminar Room Department of Physics physics@osu.edu America/New_York public

Chromatin remodelers are multidomain machines that reposition nucleosomes along genomic DNA using a helicase-like ATPase motor. Yet how the remodeler ATPase is regulated to achieve particular remodeling outcomes has been unclear. I will discuss our recent biochemical work describing the domain architecture for the Chd1 remodeler on the nucleosome. In contrast with what has been described for other remodelers, this domain organization suggests an inhibitory mechanism for sensing DNA flanking the nucleosome. I will present a model for how domain-domain communication allows Chd1 to slide nucleosomes away from bound transcription factors and generate evenly spaced nucleosome arrays.