BioPhysics Seminar - Greg Bowman (Johns Hopkins University) Recognition of the Nucleosome by a Chromatin Remodeler

October 26, 2017
Thursday, December 7, 2017 - 11:00am to 12:00pm
1080 Physics Research Building - Smith Seminar Room
Greg Bowman - Johns Hopkins University - 12/7/17 BioPhysics Seminar speaker

Chromatin remodelers are multidomain machines that reposition nucleosomes along genomic DNA using a helicase-like ATPase motor. Yet how the remodeler ATPase is regulated to achieve particular remodeling outcomes has been unclear. I will discuss our recent biochemical work describing the domain architecture for the Chd1 remodeler on the nucleosome. In contrast with what has been described for other remodelers, this domain organization suggests an inhibitory mechanism for sensing DNA flanking the nucleosome. I will present a model for how domain-domain communication allows Chd1 to slide nucleosomes away from bound transcription factors and generate evenly spaced nucleosome arrays.

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