March 25, 2021
12:00PM
-
1:00PM
Zoom webinar
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2021-03-25 11:00:00
2021-03-25 12:00:00
BioPhysics Seminar - Roya Zandi (University of California at Riverside) - Theoretical Principles of Viral Capsid Self-organization
Spherical crystals are elementary models of geometric frustration in materials, with important realizations in a range of systems from viral shells and fullerenes to particle- and molecular-coated droplets. Using continuum elasticity theory, we study the structure and elastic energy of ground states of crystalline caps conforming to a spherical surface. We find that the ground states consist of positive disclination defects and that the ground states with icosahedral subgroup symmetries in caps arise across a range of curvatures, even far from the closure point of complete shells. Further, we use Monte Carlo simulations to investigate the kinetic pathway of formation of viral shells (capsids) and find that the key for the formation of perfect icosahedral capsids is in the strength of elastic energy compared to the protein-protein interactions and the chemical potential of free subunits.
Zoom webinar
OSU ASC Drupal 8
ascwebservices@osu.edu
America/New_York
public
Date Range
2021-03-25 12:00:00
2021-03-25 13:00:00
BioPhysics Seminar - Roya Zandi (University of California at Riverside) - Theoretical Principles of Viral Capsid Self-organization
Spherical crystals are elementary models of geometric frustration in materials, with important realizations in a range of systems from viral shells and fullerenes to particle- and molecular-coated droplets. Using continuum elasticity theory, we study the structure and elastic energy of ground states of crystalline caps conforming to a spherical surface. We find that the ground states consist of positive disclination defects and that the ground states with icosahedral subgroup symmetries in caps arise across a range of curvatures, even far from the closure point of complete shells. Further, we use Monte Carlo simulations to investigate the kinetic pathway of formation of viral shells (capsids) and find that the key for the formation of perfect icosahedral capsids is in the strength of elastic energy compared to the protein-protein interactions and the chemical potential of free subunits.
Zoom webinar
America/New_York
public
