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BioPhysics seminars - Weihong Qiu (Oregon State University) Kinesin-14s: Moving Into a New Paradigm

Weihong Qiu (Oregon State University) 8/27/18 BioPhysics seminar speaker
August 27, 2018
10:30AM - 11:30AM
1080 Physics Research Building - Smith Seminar Room

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Add to Calendar 2018-08-27 10:30:00 2018-08-27 11:30:00 BioPhysics seminars - Weihong Qiu (Oregon State University) Kinesin-14s: Moving Into a New Paradigm Kinesin-14s are microtubule-based motor proteins that play important roles in cell division. They were originally thought to be minus-end-directed nonprocessive motors that exhibit directional preference toward the microtubule minus ends in multi-motor ensembles but are unable to generate processive (continuous) motility on single microtubules as individual motors. During the past 5 years, we and others have discovered several “unconventional” kinesin-14 motors that all contain the ability to generate processive motility as individual motors on single microtubules. In this talk, I will present a series of unexpected yet exciting findings from my lab that have markedly expanded current view of the design and operation principles of kinesin-14 motors. 1080 Physics Research Building - Smith Seminar Room Department of Physics physics@osu.edu America/New_York public

Kinesin-14s are microtubule-based motor proteins that play important roles in cell division. They were originally thought to be minus-end-directed nonprocessive motors that exhibit directional preference toward the microtubule minus ends in multi-motor ensembles but are unable to generate processive (continuous) motility on single microtubules as individual motors. During the past 5 years, we and others have discovered several “unconventional” kinesin-14 motors that all contain the ability to generate processive motility as individual motors on single microtubules. In this talk, I will present a series of unexpected yet exciting findings from my lab that have markedly expanded current view of the design and operation principles of kinesin-14 motors.