BioPhysics Seminar - Xuefeng Wang (Iowa State University) Integrin Molecular Tension in Cell Adhesion, Migration and Contraction

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Xuefeng Wang (Iowa State University) 2/8/19 BioPhysics Seminar speaker
February 8, 2019
11:20AM - 12:20PM
Location
1080 Physics Research Building - Smith Seminar Room

Date Range
Add to Calendar 2019-02-08 11:20:00 2019-02-08 12:20:00 BioPhysics Seminar - Xuefeng Wang (Iowa State University) Integrin Molecular Tension in Cell Adhesion, Migration and Contraction

Integrins are the major membrane proteins providing physical cell-matrix linkage and transmitting cellular force. Such force functions as both mechanical drive and regulative signal in various critical cellular functions including cell adhesion, migration and contraction. However, the tension transmitted by integrin molecules (termed as integrin tension), as the fundamental mechanical signal in integrin signaling, has been difficult to visualize and characterize, resulting in the poor understanding of its role in many cellular functions. This presentation will demonstrate innovative molecular tension tools developed in our lab. With these tools, we measure, map and manipulate integrin tension in live cells with piconewton (pN) sensitivity and submicron resolution. Our studies revealed the mechanical and regulative role of integrin tension in cell adhesion, cell migration and platelet contraction.

1080 Physics Research Building - Smith Seminar Room Department of Physics physics@osu.edu America/New_York public
Description

Integrins are the major membrane proteins providing physical cell-matrix linkage and transmitting cellular force. Such force functions as both mechanical drive and regulative signal in various critical cellular functions including cell adhesion, migration and contraction. However, the tension transmitted by integrin molecules (termed as integrin tension), as the fundamental mechanical signal in integrin signaling, has been difficult to visualize and characterize, resulting in the poor understanding of its role in many cellular functions. This presentation will demonstrate innovative molecular tension tools developed in our lab. With these tools, we measure, map and manipulate integrin tension in live cells with piconewton (pN) sensitivity and submicron resolution. Our studies revealed the mechanical and regulative role of integrin tension in cell adhesion, cell migration and platelet contraction.